The elusive phenomenon known as the runner’s high has captivated both casual joggers and seasoned athletes alike, transforming mundane workouts into euphoric experiences. While some runners seem to tap into this neurochemical bliss regularly, others slog through their miles without ever feeling its effects. Understanding the mechanisms behind this exhilarating state can help maximise its potential for anyone, regardless of their fitness level.
The Chemistry of Euphoria
Many believe that the runner’s high is predominantly caused by endorphins, the body’s natural painkillers. However, recent research suggests a more complex interplay of neurochemicals. Dr Daya Grant, a neuroscientist and mental performance expert, explains that while endorphins play a role, the true stars of the show are endocannabinoids (eCBs). These compounds, which mimic the effects of cannabis, are released during moderate to vigorous exercise and are crucial for inducing feelings of euphoria and reducing anxiety.
As Dr Grant points out, “Endocannabinoid levels increase during moderate to vigorous running efforts and remain elevated for about 30 to 45 minutes after exercise.” This surge not only contributes to mood enhancement but also aids in pain modulation and stress resilience, making it a vital component of the runner’s high.
Flow State vs. Runner’s High
It’s important to differentiate between the runner’s high and the flow state—another state of heightened performance characterised by complete immersion in an activity. Although both experiences share common neurochemical changes and can occur simultaneously, they evoke different sensations. Dr Trish Jackman, an associate professor in sport and exercise psychology, clarifies, “The runner’s high often involves a sense of euphoria, whereas flow is about being in sync with your body and mind, often making you less aware of exhaustion.”

This distinction highlights the various ways our brains respond to physical challenges, and understanding these subtleties can enhance our training experiences.
Maximising Your Chances of Achieving the High
So, what can runners do to increase their likelihood of experiencing this coveted state? Dr Grant suggests that the human brain may have evolved to reward us for enduring physical challenges, which were crucial for survival. Therefore, sustained efforts—especially at a moderate to hard intensity—tend to trigger the runner’s high most reliably.
“High-intensity interval training can produce similar neurochemical changes,” Dr Grant notes, “but it doesn’t always lead to those feelings of euphoria.” Engaging in activities that challenge your body while still being enjoyable—like navigating rugged trails or simply running in nature—can also enhance the experience. The unpredictability of outdoor environments allows for a playful element, often leading to improved mental well-being and a greater sense of achievement.
The Broader Impact of the Runner’s High
The runner’s high isn’t exclusive to running; similar euphoric states have been reported by cyclists and rowers. However, it appears that the sustained, moderate-intensity nature of running makes it particularly conducive to this experience. For those who fail to experience the high, there remains a wealth of benefits associated with running, including improved cognitive function and stress resilience.

Interestingly, the frequency of experiencing the runner’s high may not lead to an addiction to exercise in the traditional sense. Dr Grant explains that while running can enhance brain structure over time—such as increasing the volume of the hippocampus, which plays a role in learning and memory—there’s no direct evidence linking repeated runner’s high episodes with structural changes in the brain.
Why it Matters
Understanding the dynamics of the runner’s high offers a deeper appreciation for the psychological and physiological benefits of running. While not everyone may experience this euphoric state, the act of running itself can cultivate resilience, boost mood, and enhance overall well-being. Embracing the journey, irrespective of the outcome, can transform an ordinary run into an extraordinary adventure—one that rewards effort with a sense of accomplishment and joy.