The upcoming NFL slate features a marquee Monday night clash between the Buffalo Bills and the Los Angeles Rams, alongside a London showdown that pits the Philadelphia Eagles against the Jacksonville Jaguars. Across the weekend, several other contests promise intriguing storylines, from the Buccaneers’ struggle against the Cowboys to the Vikings’ visit to a struggling Saints squad. Below is a rundown of each game, the latest lines and the projected scores.
Monday Night Showcase: Bills at Rams
The Buffalo Bills (3‑1) travel to face the Los Angeles Rams (2‑2) on Monday night. Los Angeles enters as a 2½‑point favourite and has covered the spread in just four of its last ten outings. Pro Picks favours the home side in a tight contest, forecasting a 27‑24 victory for the Rams. Buffalo must curb its turnover habit after coughing up the ball seven times in its previous two games, while Los Angeles hopes to welcome back defensive stalwarts Aaron Donald and cornerback Jaylen Watson.
London Calling: Eagles Host Jaguars at Tottenham
In the United Kingdom, the Philadelphia Eagles (2‑2) take on the Jacksonville Jaguars (3‑1) with the Jaguars listed as 7½‑point favourites. Philadelphia will be without longtime right tackle Lane Johnson, whose abrupt retirement leaves a noticeable gap; the Eagles have an 18‑30 record when he is absent. Jacksonville averages 26 points per game and has conceded the second‑fewest points in the league. The projection sees the Jaguars prevailing 23‑18.
Early Sunday Action: Bucs, Browns, Raiders and More
Tampa Bay (0‑4) heads to Dallas (2‑2) where the Cowboys are 8½‑point favourites. The Buccaneers have failed to cover the spread in 13 straight games, the longest such streak in Super Bowl era history. Dallas posted 34 points against Houston’s defence last week and looks to build on that momentum, with a predicted score of 26‑19 in favour of the Cowboys.
Cleveland (3‑1) visits the New York Jets (1‑3), with New York favoured by 1½ points. Deshaun Watson has orchestrated three consecutive fourth‑quarter game‑winning drives, lifting the Browns to surprise division‑lead status under first‑year coach Todd Monken. Meanwhile, Jets head coach Aaron Glenn sits at 4‑17 and faces mounting pressure, although quarterback Geno Smith leads the NFL in completion percentage and has avoided interceptions after leading the league last season. The expected outcome is a Jets win, 20‑17.
Las Vegas (3‑1) travels to New England (2‑2), where the Patriots are 3½‑point favourites. The Raiders opened the 2025 season with a victory over New England but have since slumped to a 3‑14 record, leading to the departure of Pete Carroll. Conversely, the Patriots rebounded to reach the Super Bowl. Klint Kubiak and Kirk Cousins have helped steady the Raiders, while Drake Maye’s late surge powered New England to a big win at Buffalo the previous week. The forecast favours the Patriots, 24‑20.
Late Afternoon Slate: Vikings, Saints, Giants and Commanders
Minnesota (4‑0) goes to New Orleans (1‑3) with the Vikings laying 2½ points. Minnesota’s success stems from a stifling defence and standout special teams play. Quarterback Kyler Murray needs to ignite the offence, building on a strong finish from the previous week. The Saints, still smarting from a primetime humiliation by the Falcons on the 20th anniversary of the Superdome’s post‑Katrina reopening, are trying to avoid a third straight home loss. The Tyler Shough‑Chris Olave connection has been a bright spot, and New Orleans holds an 8‑2 record against the spread in its last ten games. An upset pick favours the Saints, 17‑16.
New York (3‑1) travels to Washington (1‑3), with the Commanders listed as 3‑point favourites. Quarterback Jameis Winston has guided the Giants to two victories, each secured by defensive interceptions inside the five‑yard line on back‑to‑back weeks. Washington may welcome back Jayden Daniels, who would wear a brace to protect his left elbow. Oddsmakers anticipate the version of Washington that defeated Seattle to appear, projecting a Commanders win, 26‑20.
Primetime and Night Games: 49ers‑Seahawks, Ravens‑Falcons
San Francisco (4‑0) visits Seattle (3‑1), where the Seahawks are 3‑point favourites. The 49ers have remained effective despite a raft of injuries; quarterback Brock Purdy has avoided sacks altogether and is performing at an MVP level
