In a pressing appeal to the public, the NHS has highlighted a significant rise in the demand for blood transfusions to treat sickle cell disease, urging more individuals from Black and mixed Black heritage backgrounds to donate. This increase comes as the number of patients requiring specially matched blood has skyrocketed by 132% over the past decade, with the latest statistics revealing over 191,000 units requested in just the last year.
Rising Demand for HbS-Negative Blood
The urgent requirement for haemoglobin S (HbS)-negative blood, which is essential for patients suffering from sickle cell anaemia, has sharply increased. In 2015, the NHS needed 82,181 units of this critical blood type; by last year, that demand had surged to an alarming 191,000 units. This escalation underscores the growing needs of a patient population predominantly comprised of individuals from African and Caribbean backgrounds, with approximately 17,000 people living with the condition across England.
HbS is a type of haemoglobin that causes red blood cells to adopt a crescent or ‘sickle’ shape, leading to reduced flexibility and increased risk of blockages in blood vessels. For transfusion purposes, it is crucial that these patients receive blood that lacks HbS to avoid exacerbating their condition. The NHS Blood and Transplant service (NHSBT) has recognised this urgent need and is actively seeking more donors from diverse backgrounds.
The Importance of Diverse Donors
John James, chief executive of the Sickle Cell Society, voiced the urgency of the situation, stating, “These figures show an urgent need for more blood donors, especially from Black and brown heritage communities.” He emphasised that the blood types most crucial for sickle cell patients are more frequently found within these communities, which remain significantly underrepresented among blood donors.

In response to this challenge, the Sickle Cell Society has partnered with NHSBT to launch the “Give Blood, Spread Love” initiative. This programme aims to increase the number of Black-heritage donors, promoting the message that donating blood is a straightforward act that can save or enhance the lives of up to three individuals.
Factors Behind the Surge
Several factors contribute to the heightened demand for blood transfusions in sickle cell patients. An ageing population, advancements in transfusion methods, and an increasing number of patients from regions where sickle cell disease is more prevalent have all played a role. Additionally, many individuals with sickle cell develop antibodies that necessitate highly compatible blood, complicating the transfusion process.
Chiara Vendramin from NHSBT noted, “Beyond the HbS-negative requirement, there are many other blood group types to consider. Patients can develop antibodies over time, which makes it harder to find compatible blood and can delay treatment.” This complexity further underscores the importance of diversifying the donor pool, as individuals from similar ethnic backgrounds are more likely to share compatible blood types, thereby facilitating quicker and more effective treatment.
Conclusion: The Need for Action
The NHSBT has issued a clarion call, stating, “The best matched blood will often come from someone of the same ethnic background.” While there has been a notable increase in Black-heritage donors, the organisation stresses that a significant need persists for more individuals to step forward, especially those with rare blood types prevalent in the Black community.

Why it Matters
The growing demand for blood donations from Black communities is not merely a statistic—it’s a critical issue that impacts thousands of lives. As sickle cell disease continues to affect a notable segment of the population, the call for action is clear. By increasing participation in blood donation, we can ensure that those facing the challenges of this debilitating condition receive the care they desperately need. This is not just about health; it’s about community solidarity and the shared responsibility to support one another in times of crisis.